Prediction of Hemodynamic Reactivity During General Anesthesia Using Analgesia/Nociception Index (ANI)

Prediction of Hemodynamic Reactivity During Desflurane/Remifentanil General Anesthesia Using Analgesia/Nociception Index (ANI)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01839513

Enrollment

100

Registered

2013-04-25

Start date

2013-05-31

Completion date

2013-11-30

Last updated

2013-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

Analgesia/nociception index, Desflurane, Remifentanil, Orthopedic surgery, Ear-nose-throat surgery, Hemodynamic reactivity

Brief summary

The aim of this study is to evaluate the performance of Analgesia/Nociception Index for the prediction of hemodynamic reactivity in adult patients undergoing ear-nose-throat or lower limb orthopedic surgery on desflurane/remifentanil general anesthesia.

Detailed description

Measurement of analgesia/nociception index at different time points during procedure and assessment of analgesia/nociception index to predict hemodynamic reactivity by building receiver observer's characteristic curve.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Age 18-75 years * Ear-nose-throat or lower limb surgery * General anesthesia using desflurane and remifentanil

Exclusion criteria

* Age \<18 yrs or \>75 yrs * Arrythmia * Preoperative use of B-blockers * Administration of anticholinergic drugs or neuromuscular blockade reversal in the 20 previous minutes * Psychiatric diseases * Autonomic nervous system disorders (epilepsy)

Design outcomes

Primary

Measure	Time frame
Change in heart rate and/or systolic blood pressure by more than 20% within 5 minutes	Before induction of anesthesia, 1 min after incision, at steady-state anesthesia during procedure (an expected average of 30 min) and at arousal from general anesthesia in the end of procedure (an expected average of 60 min)

Countries

France

Outcome results