Orthognathic Surgery
Conditions
Keywords
antihypertensive agents, hemodynamic, anesthetics reduction, orthognathic surgery
Brief summary
For those who receive hypotensive anesthesia in orthognathic surgeries, the investigators premedicate with anti-hypertensive agent so that it decreases the occurence of tachycardia and the rebound hypertension due to hypotensive anesthesia, enabling us to compare hemodynamic stability and reduction of anesthetic agents during the operation.
Interventions
DRUGb-blocker(Atenolol)
DRUGACE inhibitor(Enapril)
OTHERcontrol
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 29 Years
Healthy volunteers
No
Inclusion criteria
1. ASA class I-II 2. obtaining written informed consent from the parents 3. aged 18-29 years who were undergoing orthognathic surgery.
Exclusion criteria
1. Hypertension patients with anti-hypertensive agents 2. chronic renal failure or End stage renal disease patients. 3. renal artery stenosis history. 4. Patients who are with medication due to systemic disease. 5. symptomatic asthma 6. Drug hyperactivity 7. neurological or psychiatric illnesses 8. mental retardation 9. patients who can't read the consent form due to illiterate or foreigner
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the influence of antihypertensive agents on hemodynamic stability | From the beginning until the end of hypoetensive anesthesiaan expected average of 65 mins.(From manipulration of Mandible to maxilla) | Total minutes when the MAP is lower than 55mmHg and higher than 65mmHg (min) , The time below 55 mmHg(min) , The total time above 65 mmHg (min) Total remifentanil amount, total NTG amount, total phenylephrine amount Arterial gas analysis 4 times after induction, at the start of manipulation of mandible, at the start of manipulation of maxilla, at the end of surgery. Pr-operative and post-operative lab (Hb, Bun, Cr, OT, PT, Na, K) Intraoperative total fluid, total urine amount, total blood loss, transfusion amount. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| reduction of anaesthetics with control | From the beginning until the end of hypoetensive anesthesia an expected average of 65 mins.(From manipulration of Mandible to maxilla) | Total minutes when the MAP is lower than 55mmHg and higher than 65mmHg (min) , The time below 55 mmHg(min) , The total time above 65 mmHg (min) Total remifentanil amount, total NTG amount, total phenylephrine amount Arterial gas analysis 4 times after induction, at the start of manipulation of mandible, at the start of manipulation of maxilla, at the end of surgery. Pr-operative and post-operative lab (Hb, Bun, Cr, OT, PT, Na, K) Intraoperative total fluid, total urine amount, total blood loss, transfusion amount. |
Countries
South Korea
Outcome results
None listed