Bioimpedance Spectroscopy for the Differential Diagnosis of Hyponatremia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01838759

Enrollment

Registered

2013-04-24

Start date

2013-02-28

Completion date

2013-09-30

Last updated

2014-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyponatremia

Keywords

Bioimpedance spectroscopy, Hypervolemia, Hypovolemia

Brief summary

We aimed to investigate the role of bioimpedance spectroscopy for the diagnosis of hyponatremia

Detailed description

* Up to now, Hyponatremia differentially diagnosed by physical examination, plasma and urine osmolalities, Echocardiography and biochemical measurements. * The purpose of this study is to determine whether bioimpedance spectroscopy can be used for the detection of hypovolemia and hypervolemia for the differential diagnosis of hyponatremia.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Willing to participate in the study with written informed consent * Older than 18-years

Exclusion criteria

* The presence of pacemaker or defibrillator * Artificial joints, pin or amputation * Pregnancy or lactating.

Design outcomes

Primary

Measure	Time frame	Description
Accuracy of volume status measured by bioimpedance spectroscopy	Six months	BIOIMPEDANCE SPECTROSCOPY: Overhydration (OH) measurement by Body Composition Monitor (Fresenius Medical Care) Negative values of OH indicating Hypovolemia and positive values for hypervolemia in hyponatremic patients.

Secondary

Measure	Time frame	Description
Laboratory data and echocardiography	6 Months	LABORATORY MEASUREMENTS Hemoglobin, Hematocrit, White blood cell count Platelet count, Na, Potassium, Chlorur, Urea, Creatinine, Uric acid, Plasma osmolality, Urine osmolality, Alanine transaminase , Aspartate transaminase , Urine specific gravity, TREATMENT MODALITY 1. Diuretics 2. Intravenous hydration by isotonic saline ECHOCARDIOGRAPHY: Left ventricular end-diastolic diameter, Left ventricular end-systolic diameter, Ejection fraction(%), Left Atrium diameter, Aortic diameter, Right atrium diameter, Interventricular septum, Posterior wall thickness, Mitral insufficiency, Pulmonary insufficiency, Systolic pulmonary artery pressure, Tricuspid insufficiency

Countries

Turkey (Türkiye)

Outcome results