Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft

Intracranial Atherosclerosis and Predictors of Post-CABG Depression

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01838356

Acronym

NOAHS

Enrollment

169

Registered

2013-04-24

Start date

2012-09-30

Completion date

Unknown

Last updated

2018-01-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Depression, Intracranial Atherosclerosis

Keywords

Depression, Vascular depression, Intracranial atherosclerosis, Coronary artery disease, Coronary artery bypass graft, Cognitive impairment

Brief summary

The purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery. The main hypothesis of the study states that pre-surgical blood flow in the brain will be an independent risk factor for depression after surgery after adjusting for other risk factors such as gender, pre-CABG depression, social support, medical comorbidity burden, socioeconomic status, and neuroticism.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age: 40 years or older * Will be having CABG surgery at the Yale New Haven Hospital * Be able to provide informed consent * Have a household telephone * A fluent English speaker, and possessing no communication barrier * Be able to come to the study site or to have the study team come to his/her home. * Has a family member or partner/ friend who could provide collateral information

Exclusion criteria

* Has had previous CABG surgery * History of dementia diagnosis or cognitive impairment (CDR \>/= 1) * Auditory or visual impairment that would interfere with study procedures * Active alcohol or substance abuse problem based CAGE-AID (endorsing two or more items) * History of Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, or any Psychotic Disorder by medical history or self-report. * Presence of non-cardiovascular conditions likely to be fatal within 1 year

Design outcomes

Primary

Measure	Time frame
Pre-surgical intracranial atherosclerosis as measured by transcranial doppler ultrasound relative to depressive symptoms post-surgically as measured by DISH.	12 months

Secondary

Measure	Time frame	Description
Examine neurocognitive function relative to post-CABG depression through a series of neurocognitive tests.	12 months	Neurocognitive tests are aimed at evaluating memory, processing speed, and global cognition.

Countries

United States

Outcome results