Hypertension
Conditions
Brief summary
Guidelines recommend measuring end organ damage and in particular arterial stiffness in patients with hypertension. However, until now it was not possible to measure arterial stiffness with the use of simple methods. Recently, novel and innovative devices offering determination of arterial stiffness and central hemodynamics from simple and non-invasive arm cuff measurements have now become available. This study therefore evaluates the value of non-invasively measured arterial stiffness and central hemodynamics for guiding antihypertensive treatment in selected patient populations (i.e. elderly patients, patients with diabetes mellitus, patients with heart failure, and patients with resistant hypertension).
Interventions
OTHEROptimization of blood pressure according to guidelines
There is no specific recommendation for the intervention. The goal of the intervention is an optimization of blood pressure control. The intervention is at the discretion of the physician, but should adhere to guidelines. The intervention may therefore embrace measures such as drug prescriptions or lifestyle interventions.
Sponsors
Luzerner Kantonsspital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients \>70 years (elderly cohort) * Patients with diabetes mellitus (diabetes cohort) * Patients with heart failure (heart failure cohort) * Patients with resistant hypertension (resistant hypertension cohort)
Exclusion criteria
* Patient refuses study participation * Severe renal failure * Reduced life expectancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial stiffness and central hemodynamics | 3 months | Non-invasive measurement of arterial stiffness and central hemodynamics with the Tensiomed Arteriograph device |
| Cognitive function | 3 months | Measurement with Mini Mental State Exam and Verbal Recall Test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physical function | 3 months | Measurement with gait speed, hand grip test and physical activity questionnaire |
| Orthostatic hypotension and falls | 3 months | Measurement with blood pressure recordings and structured questionnaire |
| Renal failure | 3 months | Creatinine measurement |
Countries
Switzerland
Contacts
Primary ContactPaul Erne, MD
Backup ContactAndreas W Schoenenberger, MD
Outcome results
None listed