Epiphrenic III Pilot Trial

Uni- or Biventricular Pacing and Diaphragmatic Stimulation for Severe Heart Failure (Epiphrenic III Pilot Trial)

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01837771

Enrollment

Registered

2013-04-23

Start date

2013-04-30

Completion date

Unknown

Last updated

2013-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Brief summary

The Epiphrenic III Pilot Trial investigates whether a diaphragmatic stimulation by interventionally placed electrodes may improve heart function, symptoms and functional capacity in patients with severe heart failure.

Interventions

DEVICEDiaphragmatic stimulation

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Symptomatic heart failure (NYHA functional classes II, III or IV) * Reduced left ventricular ejection fraction (LVEF) \<35% * Guideline-recommended drug therapy

Exclusion criteria

* Patient refuses study participation * Life expectancy presumably \<1 year * Pregnancy

Design outcomes

Primary

Measure	Time frame
Left ventricular ejection fraction	Four weeks
NYHA functional class	Four weeks

Secondary

Measure	Time frame
Brain natriuretic peptide (BNP)	Four weeks
6-minutes walking test	Four weeks

Countries

Switzerland

Contacts

Primary ContactPaul Erne, MD

paul.erne@luks.ch++41 41 205 5208

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026