Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01837056

Enrollment

Registered

2013-04-22

Start date

2011-01-31

Completion date

2012-02-29

Last updated

2013-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uveitis

Keywords

Toxoplasma gondii, Toxocara canis

Brief summary

Investigate the prevalence of Toxoplasma gondii and Toxocara canis in Uveitis * serum antibody to T. gondii and T. canis * PCR with peripheral blood for T. gondii and T. canis * PCR with aqueous humor for T. gondii and T. canis * Clinical manifestation of patient with uveitis

Detailed description

Consecutive patients with uveitis are enrolled in Nune Eye Hospital. Serum ELISA * IgM,IgG antibody to Toxoplasma gondii * IgG antibody to Toxocara canis PCR * PCR with serum and aqueous humor to Toxoplasma gondii * PCR with serum and aqueous humor to Toxocara canis Clinical characteristics * visual acuity * intraocular pressure (IOP) * location and degree of inflammation * other fundus findings were recorded questionnaire * environment, occupation * pet ownership, exposure to animal * history of eating raw liver of animal, raw beef or any other raw flesh of animal.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* patients with uveitis

Exclusion criteria

* Patients with history of major ophthalmic surgery within 6 months * antiviral, antifungal or antiparasitic therapy within 6 months

Design outcomes

Primary

Measure	Time frame	Description
Number of patients with positive result for serum antibody to Toxoplasma gondii and Toxocara canis	at baseline	proportion of patients with seropositive for Toxoplasma gondii and Toxocara canis among patients

Secondary

Measure	Time frame	Description
Number of patients with positive PCR with peripheral blood and aqueous humor to Toxoplasma gondii and Toxocara canis	at baseline	Proportion of patient with positive PCR to Toxoplasma gondii and Toxocara canis

Other

Measure	Time frame	Description
location of inflammation and fundus finding	at baseline	location of inflammation * anterior or posterior or panuveitis fundus finding * granuloma in macular or periphery retina * pigmentation
Demographic characteristics	at baseline	* Gender * Residence * Pet ownership * Habit of eating uncooked meat

Outcome results