Coronary Artery Occlusive Disease
Conditions
Keywords
fluid responsiveness, carotid artery peak velocity variation, coronary disease
Brief summary
The aim of this study is to investigate usefulness of the respirophasic variation in carotid artery peak flow velocity measured by Doppler ultrasound, which is noninvasive and easily accessible, as a predictor of fluid responsiveness in patients with coronary artery disease.
Interventions
OTHERVolume expansion
Sponsors
Yonsei University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1\. patients scheduled for elective isolated off-pump coronary artery bypass graft surgery
Exclusion criteria
1. cardiac rhythm other than sinus 2. congestive heart failure 3. left ventricular ejection fraction \<35% 4. history of transient ischemic attack 5. pre-existing cerebrovascular disease and peripheral arterial occlusive disease 6. presence of carotid artery stenosis \>50%
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predictive power of the respirophasic carotid flow peak velocity variation for the fluid responsiveness | Measurement of respirophasic carotid flow peak velocity variation before the volume expansion | After induction of anesthesia, peak velocity of carotid artery blood flow is measured by the pulsed wave Doppler signal obtained from the left common carotid artery. Respirophasic variation of the peak velocity is defined as the difference between the maximum and the minimum values of peak velocity divided by the mean of the two values during one respiratory cycle. Fluid responder is defined as a patient whose stroke volume index is increased ≥15% after volume expansion. The receiver operating characteristic curve analysis to descriminiate fluid responder is performed. |
Countries
South Korea
Outcome results
None listed