Urological Disease
Conditions
Brief summary
Propofol can be measured continuously in breath gas during anesthesia. This study compares propofol concentration in plasma and breath gas and processed electroencephalographic monitoring (bispectral index) under clinical conditions with patients and total intravenous anesthesia. Target controlled infusion technique is used to deliver adequate propofol concentration in plasma.
Interventions
DEVICEDrug: Propofol Anesthesia Patients will undergo propofol anesthesia.
Sponsors
Draeger
University of Luebeck
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
• 18 years of age * Written informed consent * Ability and willingness to give written informed consent * American Society of Anesthesiologists (ASA) risk score I-II
Exclusion criteria
* Denial of the patient * Patients ASA physical status III- IV * Pregnancy * Volunteers with history of neurological disease or stroke * Volunteers with a history of recreational drug abuse * Volunteers with a history of alcohol abuse * Known drug allergies * History of adverse events during general anesthesia * Total intravenous anesthesia not practicable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exhaled propofol (parts per billion) | Continuous measurement over 40 min during the induction of anesthesia and 30 min during recovery of anesthesia |
Countries
Germany
Outcome results
None listed