Patellar Tendinopathy - Effect of Training and Enhancement of the Collagen Synthesis by Insulin-like Growth Factor-I

Effect of Training and Local Infusion of Insulin-like Growth Factor-I and Training on Tendon Structure in Patients With Patellar Tendinopathy

Status

UNKNOWN

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01834989

Acronym

IGF-I

Enrollment

Registered

2013-04-18

Start date

2013-04-30

Completion date

2020-12-01

Last updated

2020-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tendinopathy

Brief summary

The purpose of the study is to test the hypothesis that stimulation of the synthesis of new structural tendon proteins combined with training improve the tendon structure in patients with chronic knee tendon pain.

Detailed description

Randomized controlled intervention study: 12 weeks intervention period with training and injections of saline or Insulin-Like growth factor I. One year follow-up

Interventions

DRUGInsulin-like growth factor I

DRUGPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* chronic patellar tendinopathy (\> 3 months) * anterior-posterior thickening of the tendon (1 mm compared to mid-tendon) * hypo-echoic area with enhanced vascularization

Exclusion criteria

injection * corticosteroid injection within the last 12 months * Knee operation * Knee osteoarthritis * Diabetes * Smoking * Body mass index \>30

Design outcomes

Primary

Measure	Time frame
Tendon structure	After 12 weeks intervention (tendon biopsy)

Secondary

Measure	Time frame	Description
Tendon Pain	1 year (before and after 12 weeks intervention and 1 year after intervention start)	questionnaire

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026