Cognitively Healthy Subjects Influenced by Psychoactive Drugs
Conditions
Keywords
chess, cognition
Brief summary
Effects of caffeine, methylphenidate, modafinil and placebo on cognitive performance of chess players in chess games and neuropsychiatric standardized tests. We hypothesize that substances will change cognitive performance in chess players leading to changed results in chess games and neuropsychiatric tests.
Interventions
DRUGDrugs use: methylphenidate
40 mg tablets
DRUGDrug use: modafinil
40 mg tablets
DRUGcaffeine
400 mg
DRUGplacebo
placebo
Sponsors
K. Lieb
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* male * 18-60 years old * existence of ELO-number
Exclusion criteria
* physical diseases (e.g. diabetes mellitus, etc.) with necessity of using prescription drugs * psychiatric diseases (e.g. psychosis, bipolar disorders, etc.) with necessity of using prescription drugs * addiction of psychoactive substances * smoker or quitter (\< 5 years) * use of more than 5 cups of coffee per day * irregular day-night-rhythm (e.g. shift workers)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chess games (win/ lose/ tie) | two years |
Secondary
| Measure | Time frame |
|---|---|
| time period for decision of chess games | results of ches games |
| Cognitive performance measured with standardized neuropsychiatric tests (Tower of Hanoi, Trail-Making test, Stroop-Test, Psycho-Motor-Vigilance test, Wisconsin-Card-Sorting-Test, Balloon Analog Risk Task) | outcome of tests |
| measuring of risk taking behaviour, motivation, mood using standardized questionnaires | outcome of tests |
| adverse events | type of adverse events |
Countries
Germany
Outcome results
None listed