Duodenal Fistula, Inflammatory Intestinal Obstruction, Severe Acute Pancreatitis Patients
Conditions
Brief summary
Different studies suggest that early enteral nutrition (EEN) has benefits in reducing infectious complications, there is no data that addresses whether delayed enteral nutrition (EN) is detrimental and if it may have effects on inflammatory responses and immune function.
Interventions
DIETARY_SUPPLEMENTenteral nutrition
Sponsors
Nanjing PLA General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* having a fasting time of more than 14 days * American Society of Anesthesiologists (ASA) physical status ranging between 1 and 3, and their condition allows enteral nutrition therapy.
Exclusion criteria
* chronic renal failure (peritoneal or hemodialysis or creatinine \> 2.5 mg/dl) * history of chronic obstructive pulmonary disease * hepatic dysfunction or cirrhosis or a bilirubin value \> 3 mg/dl * metabolic diseases,severe anemia * blood coagulation dysfunction * pregnancy lactation * history of psychiatric illness * patients underwent immunosuppressive therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| all cause mortality | 28 days |
Secondary
| Measure | Time frame |
|---|---|
| organ failure | 7 days |
Other
| Measure | Time frame | Description |
|---|---|---|
| inflammatory markers | 7 days | white blood cell count, C reactive protein(CRP), pro-inflammatory cytokines (TNF-a,IL-1,IL-6), and anti-inflammatory cytokines (IL-4, IL-10) |
Outcome results
None listed