Diagnosis of Subclinical Urinary Tract Infections Using Advanced Microbiome Survey Techniques in High Risk Trauma Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01834391

Enrollment

129

Registered

2013-04-17

Start date

2013-03-31

Completion date

2015-09-30

Last updated

2016-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urinary Tract Infection

Brief summary

The purpose of this study is to see if the investigators can identify early those patients who are admitted to the hospital and have a urinary tract infection (UTI) or those patients that develop a UTI during their hospitalization.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* 65 years old or older admitted as a result of trauma to Saint Marys Hospital at Mayo Clinic

Exclusion criteria

* Prisoners * Pregnancy * Active urinary tract stones * Less than 65 years of age

Design outcomes

Primary

Measure	Time frame	Description
Identify of bacteria, genes and proteins that are highly predictive of UTI development	Nine months	To identify which bacteria, genes and proteins will be highly predictive of UTI development in geriatric trauma patients. We hypothesize that the combination of 16S rDNA and metaproteomics will identify the most informative biosignatures (species/genes/proteins) discerning UTI from asymptomatic bacteriuria.

Secondary

Measure	Time frame
Biomarker candidates for UTIs recalcitrant to antibiotic treatment.	Nine months
Morbidity	9 months
Mortality	9 months

Countries

United States

Outcome results