Abdominal Aortic Aneurism, Ischemic Reperfusion Injury, Surgery
Conditions
Keywords
Abdominal Aortic Aneurism, Endothelia, Glycocalyx, Reperfusion, Plasma
Brief summary
The investigators want to measure the degradation of the endothelial glycocalyx before and after clamping the aorta, in patients operated for a abdominal aortic aneurism.
Detailed description
50 patients is scheduled for enrollment. Blood samples will be up taken before surgery, 10 min after reperfusion, at the end of surgery and the following morning. In addition the investigators are placing a renal venous catheter where blood samples will be up taken as mentioned above for the analysis of endothelial markers together with markers for kidney damage. The first 10 patient will act as part of a pilot study, where only measurement of the endothelial and renal failure markers will be performed.
Interventions
OTHERPlasma
2 Units of plasma transfused equvilant to 2 times 275ml
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* above 18 years
Exclusion criteria
* prior engagement in scientific study within the last 30 days.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial dysfunction | 24 hours | Measurement of endothelial markers peri- and postoperative: thrombomodulin, E-selectin and syndecan-1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fluid balance | 24 hours | Perioperative and postoperative first 24 hours |
Other
| Measure | Time frame | Description |
|---|---|---|
| Postoperative organ failure | 30 days | Development of kidney- and respiratory failure and sepsis |
Countries
Denmark
Contacts
Primary ContactThomas B Jørgensen, MD
Outcome results
None listed