Thyroid Cancer
Conditions
Keywords
thyroid cancer, radioiodine treatment, xerostomia, sialadenitis
Brief summary
The purpose of this study is to determine whether the use of honey mouthwashes in the prevention of salivary side effects of 131I (radioiodine) therapy.
Interventions
DIETARY_SUPPLEMENTthymus honey mouthwash
Based on the intervention, each patient will be instructed to suck 1 or 2 lemon candies every 2-3 h in the daytime plus 4 thymus honey mouthwashes in between (at least one hour after the candy sucking) starting 12 hours after the ingestion of 131I therapy and for a duration of no more than 4 days.
Sponsors
Cyprus University of Technology
Bank of Cyprus Oncology Centre
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* \>18 years old * They had a histological diagnosis of papillary, follicular, medullary or anaplastic thyroid cancer * They had undergone total thyroidectomy * They were able to provide consent
Exclusion criteria
* patients who had distant metastases, * a history of salivary-gland disorders, * collagen tissue disease * diabetes mellitus, * previous radioiodine therapy or external radiation to the head or neck * allergy to the honey
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grade of sialadenitis | Change from Baseline grade of sialadenitis at 6 and 24 months |
Secondary
| Measure | Time frame |
|---|---|
| Grade of Xerostomia | Change from Baseline grade of xerostomia at 6 and 24 months |
| Level of Health related quality of life | Change from Baseline level of health related quality of life at 6 and 24 months |
Countries
Cyprus
Contacts
PRINCIPAL_INVESTIGATORAndreas Charalambous, PhD
Cyprus University of Technology
Outcome results
None listed