Laparoscopic Colorectal Surgery
Conditions
Brief summary
Remote ischaemic preconditioning may confer the cytoprotection in critical organs. The investigators hypothesized that limb remote ischemic preconditioning (RIPC) would reduce heart and gastrointestinal function injury in middle-aged and elderly patients undergoing elective laparoscopic colorectal surgery.
Interventions
PROCEDURELimb remote ischemic preconditioning (LRIP)
Limb remote ischemic preconditioning (LRIP) consisted of three cycles of left upper limb ischemia induced by inflating a blood pressure cuff on the left upper arm to 200mmHg, with an intervening 5 minutes of reperfusion, during which time the cuff was deflated.
Sponsors
Fei Li
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \>40 years old * ASA I-II * receive elective laparoscopic colorectal surgery * written informed consent can be obtained
Exclusion criteria
* coagulation disorders * patients with cardiac pacemaker * patients with severe cardiac,or pulmonary,hepatic,renal disease ,or can not tolerate laparoscopic surgery * patients with peripheral vascular disease affecting the upper limbs * patients with mental,or hearing, vision disorder, who is not able to communicate with physicians * difficult airways that can not receive rapid induction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Limb remote ischemic preconditioning may have effective protection of heart and intestinal in middle-aged and elderly patients undergoing elective laparoscopic colorectal surgery. | within the first 7 days after surgery | We hypothesized that limb remote ischemic preconditioning (RIPC) would reduce heart and intestinal injury in patients undergoing elective laparoscopic colorectal surgery.The primary outcomes included the biomarkers reflecting intestinal injury (serum intestinal fatty acid binding protein, endotoxin levels and),time (hours) from end of operation to first passage of stool or flatus,the biomarker reflecting heart injury (CTnI,serum heart fatty acid binding protein ).Perioperative electrocardiographic was also recorded. In addition, the severity of intestinal injury was assessed with pathological scoring methods. Markers of systemic inflammation (CRP) were measured as well. |
Countries
China
Contacts
Primary ContactFei Li
Outcome results
None listed