Infectious Keratitis, Bacterial Keratitis, Fungal Keratitis
Conditions
Keywords
corneal ulcer, keratitis
Brief summary
The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.
Interventions
PROCEDURECollagen cross-linking
Collagen cross-linking arm will receive standard medication for corneal ulcer treatment and corneal collagen cross-linking. Standard treatment arm will receive only standard medication.
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
6 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Evidence of corneal ulcer grade II or III (bacteria or fungal, or presumed bacterial or fungal) * Age more than 6 year * Patients can understand and can follow the study protocol
Exclusion criteria
* Pregnancy by history or urine test * Evidence of herpetic keratitis * Evidence of corneal perforation * Evidence of autoimmune disease * Known allergy to study medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| decrement of infiltration size | 1 months | decrement of infiltration size between day0 and day 30 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| number of participants with adverse events | 1 months | adverse events after corneal collagen cross-linking (report in descriptive study) |
Countries
Thailand
Outcome results
None listed