Insulin Resistance, Type 2 Diabetes
Conditions
Keywords
insulin resistance, ethnic disparities, adiponectin
Brief summary
The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. The investigators also aimed to examine associations between nutritional factors and adiponectin levels.
Interventions
Sponsors
University of Colorado, Denver
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-60 years of age * BMI 20.0-34.9 m/kg2 * Mexican American with at least 3 grandparents born in Mexico or white with no grandparents of Latino descent.
Exclusion criteria
* pregnancy * breastfeeding * diabetes mellitus * blood pressure \> 160/100 mmHg * creatinine \> 1.5 mg/dl or glomerular filtration rate (GFR) \< 60 * liver function tests \> 3x upper limit of normal (ULN) * h/o heart failure * h/o eating disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total adiponectin concentration | measured once during second study visit, in fasting condition |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | Measured once, during second study visit. | Calculated from insulin and glucose values obtained during IV glucose tolerance test. |
Countries
United States
Outcome results
None listed