Varicella
Conditions
Brief summary
To investigate the safety, immunogenicity and immune effect of the Varicella vaccine after the 2nd dose vaccination in Chao yang district, Bei jing, since the 2nd varicella vaccination was promoted by Beijing Center for Disease Control and Prevention in November, 2012.
Detailed description
Breakthrough varicella cases and varicella cases were monitored to evaluate the protective effective in a large population. Make the basic evaluation of safety for the two dose of varicella vaccination Monitoring the Varicella virus origin and virus types from illness cases in Chao yang district Make the evaluation of healthy costs reduce for the varicella emergency vaccination after large number of varicella cases occurred.
Interventions
BIOLOGICALvaricella vaccine
The providers would get varicella vaccine
Sponsors
Beijing Center for Disease Control and Prevention
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
4 Years to 12 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants were between 4-12 years old * Participants were in good healthy determined through medical history, physical examination, clinical judgment of the investor
Exclusion criteria
* Having a fever (axillary temperature \>37.0℃) before enrollment; * Having a disease history of seizures, brain and mental disease and the vaccination history of allergies and convulsions; * Antibiotics allergy; * Having a problem of intramuscular injection because thrombocytopenia or other blood coagulation disorder; * Having immunodeficiency or under immunosuppression therapy, radiation therapy; * Having respiratory diseases, acute infection, chronic disease and HIV infection; * Having systemic skin rash, skin tinea, herpes; * Chronic liver and kidney disease; * Heart disease, and severe hypertension; * Have received whole blood, plasma or immunoglobulin therapy 3 months before enrollment; * Have not received other vaccination in 7 days before enrollment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of varicella after 2 dose vaccination | 5 years | Detection the Varicella virus origin and virus types from illness cases in Chao yang district |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adverse event rate of varicella vaccine after 2 dose injection | 5 years | Adverse event rate of varicella vaccine after 2 dose injection |
Other
| Measure | Time frame | Description |
|---|---|---|
| Antibody titre of varicella vaccine after 2 dose injection | 6 monthes | Antibody titre of varicella vaccine after 2 dose injection |
Countries
China
Outcome results
None listed