Irritable Bowel Syndrome
Conditions
Keywords
Diet
Brief summary
Irritable bowel syndrome (IBS) is a chronic gastrointestinal illness of unknown cause whose symptoms include abdominal pain, bloating and altered bowel pattern. Diet has been shown to influence the bacteria gut interaction. Our aim is to determine if components of the diet affect IBS symptoms by changing the bacteria gut interaction. In particular, we will measure whether after being on a diet high or low on certain factors there is a change in the timing and amount of hydrogen and methane produced by bacteria digesting lactulose and on IBS symptom severity.
Interventions
DIETARY_SUPPLEMENTFactor Altered Diet
Sponsors
Queen's University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Meet Rome III criteria for IBS * Willing to undergo dietary intervention
Exclusion criteria
* History of Gastric, Small Bowel or Colonic Surgery * History of Inflammatory Bowel Disease * Celiac Disease * Unable to come off following medications: antibiotics, laxatives, narcotics, sedatives * On a pre specified diet * Pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the Curve of Hydrogen Gas on Lactulose Breath Test | 5 hours |
Secondary
| Measure | Time frame |
|---|---|
| Change in Area Under the Curve on Lactulose Breath Test from Baseline | 5 hours |
| Change in IBS Symptom Severity Score from Baseline | 3 weeks |
Countries
Canada
Outcome results
None listed