Cost-effectiveness of Four Methods in Preventing Fissure Caries in Permanent Teeth

A Comparative Study on the Cost-effectiveness of Four Methods in Preventing Fissure Caries in Permanent Teeth

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01829334

Enrollment

329

Registered

2013-04-11

Start date

2006-06-30

Completion date

2009-05-31

Last updated

2013-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries

Keywords

dental caries

Brief summary

The aim of this proposed study is to investigate the cost-effectiveness of four methods in preventing fissure caries in permanent teeth, which is the most prevalent dental disease in primary school children in China. The four caries prevention methods are: resin fissure sealant, atraumatic restorative treatment (ART) sealant, sodium fluoride varnish, and silver diamine fluoride (SDF) solution. The specific study objectives are: 1. to describe longitudinally the clinical outcomes of using the above four methods to prevent dental caries in the pits and fissures of permanent first molars in school children, 2. to describe the cost of using the above four methods to prevent dental caries in an outreaching dental care programme in China, and 3. to compare the cost-effectiveness of the above four caries prevention methods.

Interventions

OTHERART dental sealant

ART dental sealant placed with glass ionomer material using the ART technique on permanent first molar, single-time placement and no replacement

OTHERResin dental sealant

Resin dental sealant placed on pits and fissures of first permanent molars, single-time placement and no replacement

OTHERSodium fluoride varnish

Topical application of 5% sodium fluoride varnish onto pits and fissures of permanent first molars, repeated every 6 months

OTHERSilver fluoride solution

Topical application of 38% silver fluoride solution onto pits and fissures of permanent first molars, repeated every 12 months

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

6 Years to 9 Years

Healthy volunteers

Yes

Inclusion criteria

* school children in good general health * has at least one pair of sound permanent first molars with deep occlusal fissures or fissures with signs of early caries

Exclusion criteria

* children with major systemic disease or on long-term medication * children not cooperative and refuse dental treatments

Design outcomes

Primary

Measure	Time frame	Description
dental caries	3 years	development of carious cavity after 3 years

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 20, 2026