Inactivity, Obesity, Type 2 Diabetes
Conditions
Keywords
Inactivity, Obesity, Type 2 diabetes, glucose metabolism, Lipid metabolism, Cognitive function
Brief summary
Epidemiological studies as well as both longitudinal animal and human inactivity studies indicate that low physical activity is associated with the pathophysiology of type 2 diabetes mellitus (T2DM) and obesity, and recently it has been estimated that physical inactivity (worldwide) causes 7% of the burden of disease related to e.g. T2DM. Physical inactivity, a high energy dietary intake, and T2DM are also associated with dementia, depression, and impaired cognitive function. It is critical that we understand how inactivity alters body composition, glucose and lipid metabolism, and cognitive function, if normal physical activity can prevent these changes, and if there are any differences between sexes. The present protocol is divided in several in several sub-studies: 1. To test whether and how a physically inactive lifestyle will influence body composition, glucose and lipid metabolism, and cognitive function. 2. To test whether normal physical activity can prevent the deleterious effect of a physically inactive lifestyle despite a high-caloric intake. 3. To test whether the influence of a physically inactive lifestyle combined with a high-caloric intake differs between sexes.
Interventions
BEHAVIORALfemale inactivity and hypercaloric diet
female inactivity and hypercaloric diet for 2 weeks
BEHAVIORALinactivity
inactivity for 2 weeks
BEHAVIORALinactivity and hypercaloric diet
inactivity and hypercaloric diet for 2 weeks
BEHAVIORALnormal activity and hypercaloric diet
normal activity and hypercaloric diet for 2 weeks
BEHAVIORALinactivity and iso-caloric diet
inactivity and iso-caloric diet for 2 weeks
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal physical active * Healthy * 18-40 y of age * Non-smokers
Exclusion criteria
* Pregnancy * Diabetes in family
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | 2 weeks | Area under the curve of plasma glucose and insulin levels during an oral glucose tolerance test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| visceral adiposity | 2 weeks | Amount of visceral fat is determined by MRI scans |
Other
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function | 2 weeks | Assessed by the Conner's Continuous Performance Test II 2000 |
| aerobic fitness | 2 weeks | maximal oxygen uptake (VO2max) was measured during an incremental exercise test performed on a cycle ergometer |
Countries
Denmark
Outcome results
None listed