Dental Pulp Necrosis, Disorder of Tooth Development
Conditions
Keywords
Immature teeth, Calcium Hydroxide, Blood clot, Revascularization, Revitalization
Brief summary
Both methods tested in this study disinfect the non-vital root canals and induce blood clot formation inside the root canal. One method places calcium hydroxide inside the root canal after disinfection and the blood clot is induced four weeks later. The other method performs disinfection and induction of blood clot in one appointment. The investigators hypothesize that both methods will obtain the same success rate in eliminating infection, increase in root length and canal walls thickness.
Detailed description
Collagen is placed on top of the blood clot, followed by white MTA. Glass ionomer is used to seal the access to the canal, which will be replaced by a permanent restoration 3 months later.
Interventions
PROCEDUREEndodontic Regeneration
Blood clot formation is induced in the root canal after disinfection. Collagen material is placed over the clot. The canal access is sealed with white MTA and glass ionomer restoration. Permanent restoration is placed 3 months later on top of the MTA.
Sponsors
University of Michigan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
* Healthy or having a mild systemic disease (ASA Physical Status 1 or 2), with no contraindications to the treatment. * Cooperative. * Clinical diagnosis of pulp necrosis based on cold test, electric pulp test as well as an identified cause of pulp necrosis such as caries, deep restorations, dental anomalies, history of trauma, associated with radiographic and/or clinic signs of periapical lesion. * Open apex with a diameter of at least 1mm. For teeth with more than one apical foramen, at least one foramen needs to be 1mm wide. * Tooth is restorable and periodontally stable.
Exclusion criteria
* Pregnancy. * Evidence of pathological external or internal root resorption, root fracture or ankylosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Absence of infection and inflammation. | 12 and 24 months after the induction of blood clot | clinic evaluation to determine the status of periodontal tissues |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in root length and canal wall width | Baseline and 12 months after the induction of blood clot | Radiographic evaluation of these changes at 12 m as compared to the initial x-rays |
Countries
United States
Outcome results
None listed