Observational Study of Oxygen Delivery During a Fractional Fluid Expansion

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01826253

Acronym

Enrollment

Registered

2013-04-08

Start date

2013-04-30

Completion date

2014-06-30

Last updated

2014-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypovolemia, Impaired Oxygen Delivery, Cardiac Output, Low

Keywords

Hypovolemia, Fluid challenge, Fluid expansion, Oxygene delivery, Cardiac output

Brief summary

Fluid expansion during cardiocirculatory insufficiency was helped by cardiac output monitoring. However, the goal of fluid expansion was to increase the oxygen delivery, which consider cardiac output, but also Haemoglobin which decrease during a fluid challenge. The maximalization of cardiac output could decrease the oxygen delivery if the haemodilution was too wide. The aim of this study was to describe the oxygen delivery during a fluid expansion conducted for cardiac output maximalization, following actual guidelines.

Detailed description

One group of 20 anticipated patients

Interventions

DRUGhydroxyethylstarch 130/0.4

Bolus of 100ml of HES 130/0.4 repeated until maximization of cardiac output

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults over 18 years * Patients in intensive care after cardiac surgery under mechanically ventilation and with oesophageal Doppler

Exclusion criteria

* Arrythmia * Pregnancy or childrens * Patients without cardiac output monitoring with oesophageal Doppler * Patients without medical indication for fluid expansion * Urgency surgery

Design outcomes

Primary

Measure	Time frame	Description
Measurement of oxygen delivery	only during the fluid challenge	Retrospective calculation of oxygen delivery (ml.min.m-2)during a fractional fluid expansion every 100ml of hydroxyethyl starch until cardiac output maximalization with oesophageal Doppler and arterial gazes (for PaO2 and Haemoglobin)from arterial line.

Secondary

Measure	Time frame	Description
Study of central venous saturation	only during the fluid challenge	Central venous gazes after each mini fluid challenge until cardiac output maximalization, from a central line

Other

Measure	Time frame	Description
study of cerebral and muscular oxygenation measured with near-infrared spectroscopy	only during the fluid challenge	study of cerebral and muscular oxygenation measured with near-infrared spectroscopy after each mini fluid challenge until cardiac output maximalization, from a central line

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026