Coronary Artery Disease, Valvular Heart Disease
Conditions
Brief summary
The purpose of this study is primarily to determine the effects of propofol at different concentration on the mitral valve annulus by using Tissue Doppler Imaging
Detailed description
The purpose of this study is to evaluate the effects of different concentration of propofol on patients who are undergoing cardiac surgery. The patients will receive infusion remifentanil 0.5mcg/kg/min with different target-site propofol concentration namely 1.0ng/ml, 2.0ng/ml and 3.0ng/ml. Tissue Doppler Imaging by transesophageal echocardiography will be done to assess the changes in cardiac function.
Interventions
DRUGPropofol 1.0mcg
Propofol dosage titration to achieve effect site concnetration at 1.0 mcg/ml using target controlled infusion.
DRUGPropofol 2.0mcg
Propofol dosage titration to achieve effect site concnetration at 2.0 mcg/ml using target controlled infusion.
DRUGPropofol 3.0mcg
Propofol dosage titration to achieve effect site concnetration at 3.0 mcg/ml using target controlled infusion
Sponsors
Konkuk University Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
patients undergoing cardiac surgery
Exclusion criteria
low ejection fraction \< 50% on transthoracic echocardiography atrial fibrillation pacemaker pericardial and infiltrative myocardial disease mitral annular calcification, surgical rings, prosthetic mitral valve lateral left ventricular wall motion abnormality oesophageal abnormality history of extensive radiation to the mediastinum upper gastrointestinal bleeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of systolic mitral valve annular velocity (S') | 10 min after achieving 3 different propofol concentrations | To examine the effect of Propofol at different effect-site concentration ( 1.0 ng/ml, 2.0 ng/ml and 3.0 ng/ml) on S' (systolic mitral valve annular velocity) during remifentanil-based anesthesia. |
Secondary
| Measure | Time frame |
|---|---|
| Early diastolic mitral valve annular velocity (e') | 10 min after achieving 3 different propofol concentrations |
| late diastolic (atrial contractile) mitral valve annular velocity (a') | 10 min after achieving 3 different propofol concentrations |
| ejection fraction | 10 min after achieving 3 different propofol concentrations |
| phenylephrine infusion rate | 10 min after achieving 3 different propofol concentrations |
Countries
South Korea
Outcome results
None listed