ARDS, Intra-abdominal Hypertension
Conditions
Keywords
mechanical ventilation, Intra-abdominal hypertension, positive end-expiratory pressure
Brief summary
Intra-abdominal hypertension can increase the pleural pressure, and then end-expiratory transpulmonary pressures will be turn to negative, Pulmonary atelectasis/acute lung injury/acute respiratory distress syndrome will appear. In the group of people who suffering intra-abdominal hypertension, the investigators use the pressure of esophagus to speculate the Intrathoracic pressure, and to setting PEEP in order to decrease the happening of ALI/ARDS, which may decrease morbidity in this population.
Interventions
DEVICEtitrated setting peep
titrated setting peep according to esophageal pressure in experimental group; setting peep on the patient's PaO2 and FiO2 in control group.
Sponsors
Jinling Hospital, China
Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* intra-abdominal hypertension * mechanical ventilation * sedation
Exclusion criteria
* underlying pulmonary disease * age older than 60 years and younger than 18 years * vital signs were not stable * non voluntary
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ventilator-free days | 28d | Comparison of two groups the duration of ventilation-free in 28d,ventilator-free day include weaning from mechanical ventilation more than 24h. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mortality | 28d | 28-Day mortality include patients who giving up treatment due to critical condition |
Countries
Switzerland
Contacts
Primary Contactli gang, master
Outcome results
None listed