Hypertension
Conditions
Keywords
Hypertension, Endothelial dysfunction
Brief summary
Chlorthalidone will result in improved endothelial function compared to hydrochlorothiazide as measured by flow mediated vasodilatation.
Detailed description
This is a randomized, double-blind, crossover study to evaluate chlorthalidone and hydrochlorothiazide and their effects on endothelial function in hypertensive patients. Subjects will receive chlorthalidone 12.5 mg, hydrochlorothiazide 25 mg, and placebo each for 4 weeks with a 1 week washout between study periods. Sequence of study drugs will be randomized. Flow mediated vasodilatation will be measured at baseline and after each treatment period.
Interventions
Sponsors
Creighton University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 19 or older * Diagnosis of hypertension * Current blood pressure \> 120/80 mm Hg
Exclusion criteria
* Use of a thiazide-type diuretic within the last 1 month * Known allergy to any study medications * History of gout or hyperuricemia * SCr \>/= 1.8 mg/dl or CrCl \< 25 ml/min * Pregnancy or breastfeeding or planning to become pregnant during study period * Dementia or cognitive impairment * Hypokalemia * Acute coronary syndrome or stroke within 6 months * Current use of sildenafil, tadalafil, or vardenafil
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Flow mediated vasodilatation | 4 weeks | Flow mediated vasodilatation will be measured after one month on each drug and placebo |
Countries
United States
Outcome results
None listed