Adrenal Insufficiency
Conditions
Keywords
adrenal, steroids, cortisol, stress
Brief summary
Cortisol is essential for survival. The importance of cortisol response is most apparent in patients with partial or complete deficiency of glucocorticoids during stressful events such as illness or surgery.
Detailed description
It is known that cortisol and other stress hormones increase during acute myocardial infarction as well (9-11). Cardiac catheterization is an essential tool for the management of acute coronary syndrome, and for the evaluation of the burden of coronary artery disease in cardiac patients.
Interventions
None listed
Sponsors
Creighton University
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing elective cardiac catheterization, who are willing and able to give consent.
Exclusion criteria
* • Patients with .primary or secondary adrenal insufficiency. * Patients taking steroids in the doses equivalent of at least 5 mg of prednisone daily for more than 3 weeks in the previous year. * Patients undergoing cardiac catheterization in the setting of acute coronary syndrome, eg. STEMI, NSTEMI and unstable angina. * Patients with low albumin level (\<3.5 g/dL)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cortisol change | one month | On the day of the procedure a total of 4 venous blood samples for random plasma cortisol level will be obtained. Blood will be drawn at 5 minutes prior to the procedure, at 30 minutes and 60 minutes during the cardiac catheterization. Another sample will be drawn in 3 hours after cardiac catheterization prior to the patients discharge. a cortisol level will be drawn at a nonstressful visit |
Countries
United States
Outcome results
None listed