A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01822431

Enrollment

100

Registered

2013-04-02

Start date

2011-06-30

Completion date

Unknown

Last updated

2013-04-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autonomic Neuropathy

Brief summary

This study will examine if one of the following methods: pupillometry, spectral analysis of heart rate variability and metaiodobenzylguanidine scintigraphy, is more capable to detect early diabetic autonomic neuropathy in patients with type 1 diabetes mellitus

Interventions

RADIATIONmetaiodobenzylguanidine scintigraphy

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

* Type 1 diabetes mellitus

Exclusion criteria

* Type 2 diabetes mellitus * Severe cardiac autonomic neuropathy * Medications other than insulin * Ocular disease other than refractive eye disorders * History of neurologic disease * History of cardiovascular disease * Thyroid disease * Vitamin B insufficiency * Other possible cause for autonomic failure

Design outcomes

Primary

Measure	Time frame
number of participants with abnormal results	1 day (at time of examination)

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026