Pistachios, Performance, Metabolomics

Influence of Pistachios on Performance and Exercise-induced Inflammation, Oxidative Stress, and Immune Dysfunction in Athletes: a Metabolomics-based Approach.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01821820

Enrollment

Registered

2013-04-01

Start date

2013-03-31

Completion date

2014-07-31

Last updated

2015-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation, Oxidative Stress, Immune Dysfunction

Keywords

Inflammation, Oxidative stress, Immune dysfunction, Metabolites

Brief summary

Ingestion of 3 ounces of pistachio nuts per day for two weeks before and the day of cycling intensely for 75 kilometers will support substrate utilization during exercise (as determined through metabolomics) and improve performance compared to water only, and attenuate inflammation, oxidative stress, and immune dysfunction during 24 hours of recovery.

Interventions

OTHERPistachios

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Male endurance cyclists * Capable of exercising for 2.5 h at a high intensity in the lab * Ages 18-55 * Agree to train normally and stay weight stable. * Agree to avoid the use of large dose vitamin/mineral supplements * Agree to avoid herbs and medications that influence inflammation

Exclusion criteria

* Regularly take supplements or medicines known to effect inflammation. * At moderate or high risk for cardiovascular disease. * Younger than 18 or older than 55 years of age. * No history of competing in cycling races.

Design outcomes

Primary

Measure	Time frame	Description
Shifts in metabolites (metabolomics)	14-day period	Shifts in metabolites pre-and post-14-days supplementation, and then after 75-km cycling, and the next morning.

Secondary

Measure	Time frame	Description
Inflammation	14-day period	Pre- and post-14 d supplementation, and following 75-km cycling; plasma IL-6, IL-8, IL-10, TNF-alpha, G-CSF, MCP-1; C-reactive protein
Immune Function	14-day period	Pre- and post-14 days supplementation, and following 75-km cycling; granulocyte and monocyte phagocytosis and oxidative burst activity; leukoycte differential
Oxidative Stress	14-day period	Pre- and post-14 days supplementation, and following 75-km cycling; RBC glutathione, protein carbonyls, ORAC, FRAP, F2-isoprostanes

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026