Cardiac Output, Fluid Responsiveness
Conditions
Keywords
Shock, Fluid bolus, Cardiac output, Children in intensive care
Brief summary
A study to determine if echocardiographically derived parameters, plethysmographic variability index and pulse pressure variation predict fluid responsiveness in children on PICU.
Detailed description
A study to determine if echocardiographically derived parameters, plethysmographic variability index and pulse pressure variation predict fluid responsiveness in children on PICU. These parameters will be measured pre and post fluid bolus in children prescribed fluid bolus therapy for clinical indications on the PICU. Children will be classified as responders (\>10% increase in cardiac output) and non responders (\<10% increase). Appropriate statistical tests will be performed to determine the most useful predictor of an increase in cardiac output following a fluid bolus.
Interventions
OTHERUltrasound cardiac output measurement
Sponsors
Imperial College London
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Healthy volunteers
No
Inclusion criteria
* Any ventilated child requiring fluid bolus therapy on the PICU for clinical indications
Exclusion criteria
* Arrythmia * Intracardiac shunt
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fluid responsiveness | Immediate | 10% increase in cardiac output following fluid bolus |
Countries
United Kingdom
Outcome results
None listed