Bipolar Disorders, Conditions Influencing Health Status
Conditions
Keywords
bipolar disorders, euthymic, psychotherapy, Functional magnetic resonance imaging
Brief summary
This research project follows two main objectives: 1) Assess anatomical and functional cerebral abnormalities in bipolar disorder. 2) Evaluate anatomical and functional changes after the application of a psychoeducational program in these patients. Specifically, this project aims to assess neurophysiological (fMRI - activation and functional connectivity) and neuroanatomical (morphometry and diffusion tensor imaging) specificities related to bipolar disorders and the therapeutic response to the psychoeducation. The results of this thesis project would also contribute to the validation of a pathophysiological model of the bipolar disorder.
Interventions
BEHAVIORALpsychoeducation
Bipolar disorders are educated to learn about their pathology
Sponsors
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* clinical diagnosis of bipolar disorders * euthymic (Montgomery and Asberg depression rating scale \< 10, Young Mania rating scale \< 10)
Exclusion criteria
* other concomitant psychiatric disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fMRI measurement (neurophysiological [fMRI - activation and functional connectivity]) | measurements were performed at T1 and T2 (up to 3 months) | measurements were performed before (T1) and after (T2) educational program of 12 sessions .One session last one hour and half once a week (they come at the hospital for all sessions : i.e. during 12 weeks). Thus, T1 to T2 is 3 months (average). |
Countries
France
Outcome results
None listed