Optimizing DBS Electrode Placement and Programming

Optimizing DBS Electrode Placement and Programming Using a Combination of High-Field MRI, Intraoperative Electrophysiology, and Computational Modeling.

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01820390

Enrollment

Registered

2013-03-28

Start date

2013-03-31

Completion date

2015-12-31

Last updated

2014-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Essential Tremor, Parkinson's Disease

Keywords

Deep Brain Stimulation (DBS), Parkinson's Disease, Essential Tremor

Brief summary

Deep brain stimulation (DBS) has become the primary surgical therapy for the treatment of motor symptoms associated with Parkinson's disease (PD), and for essential tremor (ET). Although an effective and relatively safe procedure with expanding indications, opportunities exist for the optimization of the current procedure. The investigators therefore propose, in a group of patients undergoing DBS surgery for the treatment of PD or ET, to use a combination of high-field imaging modalities, intraoperative electrophysiology, external sensor interfaces, and computational modeling, to gather information on the utility of using these techniques to optimize DBS electrode placement and programming.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* A diagnosis of idiopathic Parkinson's disease or essential tremor * Ability to provide informed consent

Exclusion criteria

* Claustrophobia or other conditions that prevent undergoing MR imaging * MMSE score \< 23 * Significant neurological diagnosis other than PD or ET. * Idiopathic dystonia

Design outcomes

Primary

Measure	Time frame	Description
Distance between Electrophysiology Results and Modeling Predictions (mm)	1 week	A comparison between electrophysiology results and modeling predictions will be made post-operatively.

Countries

United States

Outcome results