Changes in Incretins Response and Glycemic Control After Gastric Bypass Surgery in Type 2 Diabetic Patients Versus Healthy

Study of Incretins Response and Glycemic Control: Pre Diet, After Conventional Weight Loss and in the Early Postoperative Phase After Gastric Bypass in T2D-patients.

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01820273

Enrollment

Registered

2013-03-28

Start date

2013-04-30

Completion date

2019-08-01

Last updated

2019-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Type 2 Diabetes

Keywords

Type 2 diabetes, Bariatric surgery, incretines, GLP-1, GIP, gastric bypass, foregut, hindgut

Brief summary

The purpose of this study is to determine the early changes in gut hormonal, and other metabolites with known relations to the glycemic homeostasis. The study mainly focus on these responses to food in the diabetic patient, compared to the non-diabetic, after gastric bypass surgery. Also aiming for recording changes in the earliest postoperative phase.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* clinical diagnosis of type 2 diabetes * obesity BMI \>35

Exclusion criteria

* prior bariatric surgery

Design outcomes

Primary

Measure	Time frame	Description
changes in incretines in the bariatric patient	2 months prior to surgery - 6 weeks post surgery	standardized meals prior to pre op diet, day before surgery, first day after surgery and 6 weeks after surgery.

Secondary

Measure	Time frame	Description
Diabetes control	6 weeks post surgery	resolution of t2D as early as first day after surgery

Countries

Sweden

Outcome results