Heart Attack
Conditions
Brief summary
Use of MRI and DWI to diagnose cardiac scarring after heart attack.
Detailed description
To discover new information about MRI (magnetic resonance imaging) called DWI (diffusion weighted imaging) and its ability to diagnose cardiac scarring. CMR-DE (cardiac MR with delayed contrast enhancement) evaluates if there has been scarring in the heart muscle following a heart attack. Subjects are injected with a contrast medication that makes the scarring visible if present. To prove the efficacy of DWI (diffusion weighted imaging) to provide the same images that CMR-DE (cardiac magnetic resonance with delayed contrast enhancement) provides.
Interventions
PROCEDUREDiffusion Weighted Imaging with MRI scans
Subjects will have an MRI(magnetic resonance imaging)performed. This sequence will take no longer than 10 to 15 minutes to complete. Only DWI (diffusion weighted imaging) will be added to the standard cardiac MR protocol for viability which requires contrast injection. DWI(diffusion weighted imaging) sequence does not require contrast injection.
Sponsors
University of Michigan
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Males and females 21 years of age and older * Healthy volunteers * subjects with a prior history of heart attack and prior CMR-DE imaging.
Exclusion criteria
* Women who are pregnant * Subjects with GFR \< 60 ml/min/1.73m2 * Subjects with ICD * Subjects with coronary stents incompatible with 3T
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| presence and apparent diffusion coefficient (ADC) quantification of scar on (DWI) diffusion weighted image | single occurance | Confirm the efficacy of diffusion weighted imaging in providing imaging that shows cardiac scarring without the injection of contrast. |
Countries
United States
Outcome results
None listed