Gastric Tumor, Liver Tumor, Pancreatic Tumor
Conditions
Brief summary
The aim of this study is to assess the effect of postoperative parenteral fish oil on clinical outcome and immune function after major laparoscopic abdominal surgery.
Detailed description
Postoperative patients are randomized by a sealed envelope to receive either a 50:50 (vol/vol) mixture of an oil rich in medium-chain fatty acids and soybean oil (termed MCT/LCT) or a mixture of MCT/LCT and fish oil Omegaven for 7 days. Full blood count, biochemistry and coagulation are routinely assessed. Fresh blood samples are centrifuged into plasma, red blood cells and lymphocytes then stored at -80°C pending analysis. The primary endpoint was numbers of infective complications.Secondary endpoints were other clinical outcomes, length of hospital stay, and in-hospital mortality, along with plasma immunological markers.
Interventions
DRUGMCT/LCT and fish oil
DRUGMCT/LCT
Sponsors
Wei Zhou
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
15 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing an elective major laparoscopic abdominal surgery and required at least 5 days of parenteral nutrition
Exclusion criteria
* Metabolic disease * Chronic kidney or liver failure * Shock * Contraindications for lipid administration * PN during the 15 days before hospitalisation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| infective complications | within the first 30 days after surgery |
Secondary
| Measure | Time frame |
|---|---|
| length of hospital stay | average of 2 weeks |
| plasma immunological markers | from 1 day before surgery to 7 days after surgery |
Countries
China
Contacts
Primary ContactWei Zhou, MD, PhD
Outcome results
None listed