Surgical Stress After Laparoscopic Compared to Open Liver Resection

Surgical Stress Induced Insulin Resistance and Cytokine Response After Laparoscopic Compared to Open Liver Resection

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01819688

Enrollment

Registered

2013-03-27

Start date

2007-08-31

Completion date

2008-11-30

Last updated

2013-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin Resistance

Keywords

laparoscopic liver resection, cytokine release

Brief summary

The purpose of this study is to determine whether the postoperative insulin resistance and cytokine release would be attenuated in laparoscopic compared with open liver resection.

Interventions

PROCEDURElaparoscopic liver resection

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* ASA 1-2 * left hemihepatectomy(liver resection) * left lateral sectionectomy(liver resection)

Exclusion criteria

* Patients with diabetes mellitus * drug abuse * BMI \>24 or \<18

Design outcomes

Primary

Measure	Time frame	Description
postoperative insulin resistance calculated by serum insulin and blood glucose	within the first 72hrs after operation	At baseline prior to surgery, and 3hr, 12hr, 24hr, 72hrs after operation, blood glucose and insulin was measured. Insulin resistance is assessed by the HOMAIR(homeostatic model assessment of insulin resistance) score which is calculated through the mathematic formula: HOMAIR= FI ×FG/22.5, where FI= fasting serum insulin(μU/mL), FG= fasting plasma glucose (mmol/L), and 22.5 is a constant.

Secondary

Measure	Time frame	Description
cytokine changement including IL-1β, IFN-γ, IL-4 and IL-10 before and after operation	within 5 days after operation	At baseline before operation and 0, 3hr, 12hr, 24hr, D3, D5 after operation, duplicated samples were drawn to analyze serum IL-1β, IFN-γ, IL-4 and IL-10.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026