Fluid Responsiveness Predictability
Conditions
Keywords
pulse pressure variation, fluid responsiveness, diastolic dysfunction
Brief summary
The investigators hypothesized that predictability of pulse pressure variation (PPV) on fluid responsiveness would be reduced in patients with coronary disease who have diastolic dysfunction.
Interventions
DRUGFluid loading (Voluven)
HES 130/0.4 (VoluvenⓇ, Fresenius Kabi, Graz, Austria) 8ml / kg loading during 15 minutes after induction of anesthesia on both groups
Sponsors
Yonsei University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients older than 20 years * scheduled for elective coronary artery bypass grafting * normal diastolic function (E/E' \< 8) or diastolic dysfunction (E/E' \>15) according to preoperative Echocardiographic evaluation
Exclusion criteria
* arrythmia, * reduced left ventricular function (ejection fraction \< 40%) * valvular heart disease requiring concomitant surgical correction * pulmonary hypertension (mean pulmonary arterial pressure ≥30 mm Hg) * peripheral arterial occlusive disease, pulmonary disease (asthma, chronic obstructive pulmonary disease, and lung resection) * end-stage renal disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| predictability of pulse pressure variation (PPV) on fluid responsiveness in patients with coronary disease who have normal diastolic function and diastolic dysfunction. | 10 minutes after fluid replacement | After induction of anesthesia and applying mechanical ventilation, hemodynamic parameters (including PPV measured by Philips IntelliVue MP 70®) were recorded |
Countries
South Korea
Outcome results
None listed