In Vivo Study of Sucrose and Liquid Oral Pediatric Medicines of Long-term Effect on Dental Biofilm pH

Avaliação in Vivo do Potencial cariogênico e Erosivo de Bebidas e Medicamentos pediátricos líquidos Intra-orais

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01819350

Acronym

SPMedicines

Enrollment

Registered

2013-03-27

Start date

2011-08-31

Completion date

2012-08-31

Last updated

2013-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Biofilm pH

Keywords

Dental caries, Sucrose, Oral administration, Ion Concentration of Hydrogen, Pediatric medicines

Brief summary

The aims of this study were to determine the sucrose and liquid oral pediatric medicines of long-term effect on dental biofilm pH to evaluate the cariogenic potential in vivo.

Detailed description

Te study was carried out with 12 subjects that were refrained from brushing their teeth for 28 h and did not eat or drink for at least 3 h prior to each appointment. Dental biofilm pH was measured in the cervical and proximal regions of anterior teeth with beetrode-type microelectrode coupled to a potentiometer. The biofilm was submitted nine paediatric medicines a long term and sucrose (negative control). pH measurements were taken at baseline to determine resting plaque pH and at time interval 5, 10, 15, 20, 25 and 30 minutes.

Interventions

OTHERG1, G2 and G3

Nutritional, respiratory and endocrine group applicated 12 subjects

OTHERG4 and G5

Application of trhree pediadic medidines of antibiotic group on dental biofilm 12 subjects

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 22 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 18 to 22 years; * Having Oral hygiene adequate (OHI\<1.1); * Having 20 natural teeth incluing molar; * Not havind oral disease.

Exclusion criteria

* Biofilm baseline pH \> 5,5; * Not signature consent term; * Using orthodontic appliance; * Having used medicines last 3 months; * Pregant woman.

Design outcomes

Primary

Measure	Time frame	Description
Evaluation of group respiratory, nutritional and endocrine pediatric medicines effect on dental biofilm pH	6 months	pH was measured in the cervical and proximal regions of anterior teeth dental biofilm with beetrode-type microelectrode coupled to a potentiometer

Secondary

Measure	Time frame	Description
Evaluation of sucrose antibiotic group and control negative group effect on dental biofilm	12 months	The biofilm was submitted antibiotic group and negative control group. pH measurements were taken at baseline to determine resting plaque pH and at time interval 5, 10, 15, 20, 25 and 30 minutes.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026