Spasticity, Stroke
Conditions
Brief summary
Spasticity, muscle weakness, abnormal gait pattern are co-morbidities commonly seen in stroke patients. They cause disabled condition of patients in activities of daily life and functional performance, and also accidental falls and subsequent fractures. This study is to evaluate and compare the effects of different phase injection of Botulinum Toxin Type-A at affected limbs on muscle rheological changes, muscle activity, muscle tone, functional performance, gait pattern and energy consumption in stroke patients.
Interventions
PROCEDUREBotox_A
PROCEDUREBotox_B
Sponsors
Changhua Christian Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* first-ever stroke, with spasticity within 3-months (MAS=2\ 3) * independent walking 10 meters (with assistive devices)
Exclusion criteria
* recurrent stroke, cognition impaired * lower limb fracture * received anti-spasticity injection in the past
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in the muscle tone in upper and lower extremity | 4 weeks after injection | use modified Ashworth Scale to access elbow, wrist, ankle joint muscle tone 0: normal 1. slight hypertonus, at the end-range 1+: mild hypertonus, catch when limb is moved (\<1/2) 2. moderate hypertonus,, limbs moves easily (\>1/2) 3. passive movement difficult 4. rigid |
Secondary
| Measure | Time frame |
|---|---|
| Change in the gait pattern as walking | 4 weeks after intervention |
Countries
Taiwan
Outcome results
None listed