Creatine Supplementation on Kidney Function in Resistance-trained Individuals

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01817673

Enrollment

Registered

2013-03-25

Start date

2011-07-31

Completion date

2013-02-28

Last updated

2013-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Persons

Brief summary

There is a claim that creatine supplementation might affect kidney function, especially in those consuming a high-protein diet. The aim of this study was to investigate the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet.

Interventions

DIETARY_SUPPLEMENTcreatine

20 g/d for 5 d followed by 5 g/d throughout the trial

DIETARY_SUPPLEMENTplacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* participation in recreational resistance training * consumption of a high-protein diet (≥ 1.2 g/Kg/d)

Exclusion criteria

* vegetarian diet * use of creatine supplements in the past 6 months * chronic kidney disease * use of anabolic steroids.

Design outcomes

Primary

Measure	Time frame	Description
kidney function	3 months	as assessed by 51Cr-EDTA clearance

Secondary

Measure	Time frame
proteinuria	3 months
albuminuria	3 months
serum urea	3 months
serum creatinine	3 months

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 23, 2026