Epidemiological Analysis of Vitamin D and Breast Cancer Risk in Saudi Arabian Women

Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01817231

Enrollment

240

Registered

2013-03-25

Start date

2009-05-31

Completion date

2009-08-31

Last updated

2013-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer, Vitamin D Deficiency

Keywords

breast cancer, vitamin D, 25 OH vitamin D

Brief summary

This is an analysis of de-identified data collected from 240 Saudi Arabian women, 120 with breast cancer and 120 control women, to evalyate if vitamin D status is associated with breast cancer risk.

Detailed description

Background: The role of vitamin D in breast cancer prevention is equivocal. Saudi Arabian women are thought to be at greater risk for vitamin D deficiency due to darker skin type and greater likelihood for reduced UVB radiation exposure. However, there is a lack of data regarding the vitamin D status of Saudi Arabian women and how this may relate to breast cancer risk. Objective: The purpose of this research was to evaluate the association between circulating concentrations of 25(OH)D and breast cancer risk in Saudi Arabian women. Design: A case-control study was conducted among 120 breast cancer cases and 120 controls. The study population was drawn from patients admitted to King Fahd Hospital in Jeddah, Saudi Arabia from June to August 2009. Participants completed questionnaires on diet and medical history and serum samples were collected from all women to measure circulating 25(OH)D concentrations.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Invasive breast cancer (cases) or healthy women (controls), * receiving standard medical check-ups at the women's clinic * Female, * between the ages of 18 and 75 years * BMI ≤ 40 kg/m2 * residence in Saudi Arabia for more than 5 years * absence of chronic diseases that could affect vitamin D metabolism, including renal, hepatic, endocrine, or autoimmune disease.

Exclusion criteria

receiving standard medical check-ups at the women's clinic * Male, * less than 18 or greater than 75 years of age * BMI \> 40 kg/m2 * Not a resident of Saudi Arabia for more than 5 years * Presence of chronic diseases that could affect vitamin D metabolism, including renal, hepatic, endocrine, or autoimmune disease.

Design outcomes

Primary

Measure	Time frame	Description
serum vitamin D	cross-sectional from May 2009-August 2009	assessed serum vitamin D in cases versus controls

Countries

United States

Outcome results