Hip Fracture, Vitamin D Deficiency
Conditions
Keywords
Frail elderly, Hip fracture, Vitamin D, Geriatrics
Brief summary
The purpose of this study is to assess whether all frail elderly admitted with hip fracture has a vitamin D deficiency, and if s-25(OH)D deficiency increases the risk of hip fracture in frail elderly. Frail elderly are defined as being 65 years of age or older, and living in nursing homes or senior housings. The investigators' hypotheses state that: 1. Frail elderly with hip fractures will have a suboptimal level of vitamin D. 2. Frail elderly with hip fractures are more likely to have a suboptimal level of vitamin D than frail elderly without any hip fractures during the last ten years.
Detailed description
The study examined frail elderly patients, defined as 65 of age or older and living nursing homes or senior housings. Cases where taken from a Randomised Controlled Trial (NCT01102010), where the included where frail elderly admitted with a hip fractures to the Orthopaedic Surgery Ward at Aarhus University Hospital. Controls were frail elderly, without a hip fracture in the previous ten years, admitted to the Geriatric Ward at Aarhus University Hospital. The investigators will look at all eligible patients' files and record their serum-25(OH)D levels upon admission. According to sample size calculations 92 patients are needed in the case group, and 138 patients in the control group. The inclusion period will be from the 18th of January 2010 to the 1st of October 2012 for both groups.
Interventions
None listed
Sponsors
University of Aarhus
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
, Cases: * Aged 65 or older * Living in nursing home or senior housing * Admitted with hip fracture to the Orthopaedic Ward, Aarhus University Hospital
Exclusion criteria
, Cases: * No serum-25(OH)D measurement upon admission Inclusion Criteria, Controls: * Aged 65 or older * Living in nursing home or senior housing * Admitted to the Geriatric Ward, Aarhus University Hospital
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants With Suboptimal and Optimal Levels of Vitamin D (Serum-25(OH)D) | Upon admission | Serum-25(OH)D was measured in a blood sample as an indicator of Vitamin D status |
Countries
Denmark
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Hip Fracture, Frail Elderly, Non-supplemented Frail elderly with a hip fracture who did not receive vitamin D supplementation | 121 |
| Hip Fracture, Frail Elderly, Supplemented Frail elderly with a hip fracture who received vitamin D supplementation | 83 |
| Total | 204 |
Baseline characteristics
| Characteristic | Hip Fracture, Frail Elderly, Non-supplemented | Hip Fracture, Frail Elderly, Supplemented | Total |
|---|---|---|---|
| Age, Continuous | 87 years | 83 years | 87 years |
| Nursing home | 77 Participants | 45 Participants | 122 Participants |
| Region of Enrollment Denmark | 121 Participants | 83 Participants | 204 Participants |
| Senior housing | 44 Participants | 38 Participants | 82 Participants |
| Sex: Female, Male Female | 88 Participants | 62 Participants | 150 Participants |
| Sex: Female, Male Male | 33 Participants | 21 Participants | 54 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 0 / 121 | 0 / 83 |
| serious Total, serious adverse events | 0 / 121 | 0 / 83 |
Outcome results
Primary
Number of Participants With Suboptimal and Optimal Levels of Vitamin D (Serum-25(OH)D)
Serum-25(OH)D was measured in a blood sample as an indicator of Vitamin D status
Time frame: Upon admission
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Hip Fracture, Frail Elderly, Non-supplemented | Number of Participants With Suboptimal and Optimal Levels of Vitamin D (Serum-25(OH)D) | Suboptimal level (<75nmol/l) | 106 Participants |
| Hip Fracture, Frail Elderly, Non-supplemented | Number of Participants With Suboptimal and Optimal Levels of Vitamin D (Serum-25(OH)D) | Optimal level (>75nmol/l) | 15 Participants |
| Hip Fracture, Frail Elderly, Supplemented | Number of Participants With Suboptimal and Optimal Levels of Vitamin D (Serum-25(OH)D) | Suboptimal level (<75nmol/l) | 42 Participants |
| Hip Fracture, Frail Elderly, Supplemented | Number of Participants With Suboptimal and Optimal Levels of Vitamin D (Serum-25(OH)D) | Optimal level (>75nmol/l) | 41 Participants |