Gastrointestinal Diseases, Gastrointestinal Neoplasms, Rectal Diseases, Rectal Neoplasms
Conditions
Keywords
Magnetic Resonance Imaging, Magnetic Resonance Imaging, Functional
Brief summary
The purpose of this study is to establish a reliable method for detection of rectal cancer patients with aggressive tumor at risk of metastatic disease and death by functional MRI.
Interventions
PROCEDUREnew functional magnetic resonance imaging (MRI) protocols
diffusion-weighted MRI, dynamic-contrast enhanced MRI, MR spectroscopy, blood-level oxygen dependent (BOLD) MRI
Sponsors
Oslo University Hospital
University of Oslo
University Hospital, Akershus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The patient is willing and able to give full written consent according to the protocol approved by the Regional Ethics Committee. * The patient has confirmed rectal cancer diagnosis and is scheduled to radical surgery alone or preoperative CRT followed by surgery. * The patient is ≥ 18 years. * The patient has no prior rectal cancer treatment. * The patient has adequate renal function: creatinine clearance ≥ 60 ml/minute. * The patient has signed the written informed consent according to the protocol approved by the Regional Ethics Committee.
Exclusion criteria
* The patient has contraindication to MRI or MRI contrast agent according to clinical practice. * The patient wants to withdraw for any reason during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence of metastatic disease 5 years after rectal cancer treatment | five years |
Secondary
| Measure | Time frame |
|---|---|
| Histomorphological response to preoperative chemoradiotherapy | 8 weeks |
Other
| Measure | Time frame |
|---|---|
| Detection of regional malignant lymph nodes at time of diagnosis | 8 weeks |
Countries
Norway
Outcome results
None listed