Erectile Dysfunction
Conditions
Keywords
Erectile Dysfunction, Vascular Endothelium, Counterpulsation, External
Brief summary
The purpose of this study is to investigate the efficacy of Enhanced External Counterpulsation (EECP) in patients with erectile dysfunction
Detailed description
Patients with erectile dysfunction will be randomized into two groups: EECP intervention or not. Erectile function, hemodynamic parameters, vascular endothelial function will be measured and compared.
Interventions
Enhanced external counterpulsation therapy is done by sequential inflation of 3 sets of cuffs wrapped around the lower extremities during diastole and deflation of the cuffs during systole. The systolic deflation/ Diastolic inflation sequence of EECP leads to systolic unloading and diastolic augmentation, resulting in increased blood flow in a pulsatile manner. The patients receive 35-36 hours EECP intervention, 1 -hour session every day over a 7-week period.
Sponsors
First Affiliated Hospital, Sun Yat-Sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Patients with erectile dysfunction are assigned to two groups in parallel for the duration of the study
Eligibility
Sex/Gender
MALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. men over 18 years old; 2. provide signed informed consent; 3. existence of erectile dysfunction 4. agree not to use any other erectile dysfunction treatment at least one month;
Exclusion criteria
1. history of long drug abuse; 2. pelvic, spine, brain trauma or surgery; 3. endocrine, liver, lung, kidney disease, malignancies, hematological disorders; 4. abnormal urogenital status, such as small testicle (\<2cm), penile plaques;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Erectile function evaluated by International Index of Erectile Function-5 questionnaire | 7 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial function | 7 weeks | Flow-mediated dilation：In this method,brachial artery diameter is measured before and after an increase in shear stress that is induced by reactive hyperemia (FMD). Endothelial progenitor cells：Flow cytometry to detect changes in the number of endothelial progenitor cells |
Countries
China
Contacts
Primary ContactYadong Zhang, M. D.
Backup ContactZi Wan, M. D.
Outcome results
None listed