DETECT and Retinal Outcomes in Hypertension

The Effects of Blood Pressure on Cognitive Function: Examining the Use of Bedside Neuropsychological Testing During Acute Hypertensive Events

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01815567

Enrollment

234

Registered

2013-03-21

Start date

2012-11-30

Completion date

2020-07-15

Last updated

2021-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Impairment, Hypertension, Retinal Disorder

Keywords

Hypertension, Retinal Disorder, Cognitive impairment

Brief summary

The purpose of this study is to study the impact of blood pressure on cognitive performance.

Detailed description

Four groups will be evaluated for possible impact of blood pressure on cognitive performance and retinal damage.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

1. Patients triaged to the Grady Memorial Hospital Emergency Department or Marcus Trauma Unit 2. Age \>18 and \<65 3. Documented history of hypertension plus one or more of the following: * current antihypertensive use with controlled blood pressure * elevated Emergency Department systolic blood pressure or diastolic blood pressure * OR - 4. Acutely elevated Emergency Department systolic blood pressure or diastolic blood pressure on 2 separate Emergency Department measurements in the absence of a history of hypertension * OR - 5. Normal systolic blood pressure or diastolic blood pressure in the absence of hypertension.

Exclusion criteria

1. Non-English speaking 2. Pre-visit cognitive impairment 3. Physical or psychological impairments that would prohibit comprehension and completion of DETECT testing 4. Inability to obtain adequate fundoscopic photos 5. Acute intoxication, altered mental status, or head injury within the last 6 months 6. Opiate or benzodiazepine administration by treating providers 7. Clinical condition not allowing testing.

Design outcomes

Primary

Measure	Time frame	Description
DETECT neurocognitive outcome scores (Z-scores) in association with blood pressure measures and retinal pathology (isolated retinal hemorrhage, grade III/IV hemorrhagic retinopathy)	12 months	We aim to determine the correlation (if any) between the severity of blood pressure and DETECT neurocognitive outcomes as well as the correlation (if any) between known Hypertensive retinal disease and DETECT neurocognitive outcomes. Appropriate statistical analysis will be performed to compare clinical retinal findings, BP values, and DETECT neurocognitive test outcomes. Subject level data will only be collected on the day of Emergency Department presentation. Subjects will not be followed after their initial enrollment. The study duration is projected for 12 months

Secondary

Measure	Time frame
Variance of DETECT scores (Z-score) attributed to reading level	One year study periord (12 months)

Countries

United States

Outcome results