Osteoarticular Infection
Conditions
Keywords
subcutaneous teicoplanin, osteoarticular, infections, tolerance, teicoplanin
Brief summary
This is a biomedical research, prospective, mono centric, tolerance study Of the administration of subcutaneous teicoplanin in the treatment of osteoarticular infections.
Interventions
DRUGteicoplanin
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patient over 18 years * Inpatient orthopedic surgery * Achieved a bone and joint infection documented gram + (staphylococci golden coagulase-negative staphylococci, enterococci, streptococci) * Bacteria resistant to lincosamides, quinolones and rifampicin * Bacteria susceptible to teicoplanin (MIC ≤ 4 mg / L) * Balanced patient teicoplanin administered intravenously (2 successive doses between 30 and 40 mg / mL)
Exclusion criteria
* Patient not affiliated to the social security * Pregnant and lactating women * Known hypersensitivity to teicoplanin (rash, ...) * Patients with a central catheter or an implantable chamber * Patient hemodialysis * Patient has another participant biomedical research on a drug to prevent drug interactions * Patient minor * Patient major protected (protection of the court, wardship, trusteeship) * Patient admitted for emergency or incapable of consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| measure of tolerance | 6 weeks | The frequencies of adverse reactions at the injection site SC will be measured to assess the local tolerance of teicoplanin by SC. |
Countries
France
Outcome results
None listed