Cognitive Health, Hormone Responses, Obesity
Conditions
Keywords
Bariatric surgery, Cognition, Satiety hormones, Brain networks, Inhibitory control, Food intake
Brief summary
After obesity surgery gastric bypass (GBP) patients usually lose more than 50% of its former preponderance in relative short time (\ 2 years). But knowledge of the underlying biological mechanisms of decline in body weight is still inadequate. This project intends to examine patients' background activity in the brain (i.e. the resting state activity) and brain volume using MRI both before and one year after surgery.
Detailed description
We will also investigate whether hormonal changes in response to food intake after obesity surgery is associated with patients' impulsive control when exposed to pictures of food in the MRI.
Interventions
PROCEDUREBariatric surgery
Gastric bypass surgery
BEHAVIORALBrain activity in resting state
Measure of activity in brain networks during resting state
BEHAVIORALMemory performance
Assess concentration in 2D-location task (i.e. memory game)
Sponsors
Uppsala University Hospital
Uppsala University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* female * right-handed * scheduled for bariatric surgery in the Academic Hospital of Uppsala, Sweden
Exclusion criteria
* undergone more than one bariatric surgery * suffer from mental disorders (depression, phobias, etc.) that can not be controlled with treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in background activity in the brain (resting state activity) after bariatric surgery | 1 year | Brain's basic activity and structure will be measured on 3 occasions: 4 weeks before bariatric surgery, 4 weeks after surgery and 1 year after surgery, using fMRI. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in response inhibition after bariatric surgery | 1 year | Inhibitory control to food cues will be measured on 3 occasions: 4 weeks before bariatric surgery, 4 weeks after surgery and 1 year after surgery, using a NoGo-Go task. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in memory-function after bariatric surgery (concentration) | 1 year | Memory performance will be measured on 3 occasions: 4 weeks before bariatric surgery, 4 weeks after surgery and 1 year after surgery - using a a 2D-object location task (memory game) |
Countries
Sweden
Outcome results
None listed