The Effect of High and Low Roasted Coffee on Vascular Response

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01813981

Enrollment

Registered

2013-03-19

Start date

2011-05-31

Completion date

2013-01-31

Last updated

2013-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Disease

Brief summary

Evidence suggests that a diet rich in plant phenolic compounds may induce beneficial vascular effects. Coffee is a good source of phenolic compounds called chlorogenic acids (CGA), however the level of CGA is reduced during the roasting process. The aim of this study is to investigate the effect of coffee roasting on vascular response. The investigators hypothesize that coffee roasted to a lesser extent will exert a favourable vascular response over more heavily roasted coffee due to the higher levels of CGA.

Interventions

DIETARY_SUPPLEMENTLow roast coffee

Instant coffee

DIETARY_SUPPLEMENTHigh roast coffee

Instant coffee

DIETARY_SUPPLEMENTControl (Caffeine dissolved in water)

Caffeine dissolved in water

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

MALE

Age

19 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Male * A signed consent form * Age 19-35 years * Body mass index - 18.5-30 kg/m2 * Normal blood pressure at screening (\< 150/90)

Exclusion criteria

* Blood pressure \> 150/90 mmHg * Haemoglobin (anaemia marker) \< 125 g/l * Gamma GT (liver enzymes) \> 80 IU/l * Cholesterol \> 6.5 mmol/l * Had suffered a myocardial infarction or stroke in the previous 12 months * Suffers from any reproductive disorder * Suffers from any blood-clotting disorder * Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases) * Any dietary restrictions or on a weight reducing diet * Drinking more than 21 units per week * On any lipid-modifying medication * On any blood pressure lowering medication * On any medication affecting blood clotting * Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study * Regular or vigorous exercise (3 times/week, 20 minutes each session) * Smoking * Vegetarians or vegans

Design outcomes

Primary

Measure	Time frame
Vascular response measured by flow mediated dilatation (FMD)	Change from baseline to 2 hours

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 11, 2026