Acute Hamstring Muscle Strain Injury
Conditions
Keywords
Platelet rich plasma, Interventional, Randomized, Double-blind
Brief summary
The purpose of this study is to evaluate the therapeutic benefit of utilizing complex growth factor preparations (Platelet Rich Plasma (PRP) in the management of acute hamstring injuries. The hypothesis is that the time to return to sport is shorter in the patient group treated with Complex Growth Factor Preparations (PRP) in combination with exercise therapy in comparison with 2 control groups: * the patient group treated with Platelet Poor Plasma (PPP) injections in combination with exercise therapy (control injection AND usual care). * the patient group treated with exercise therapy (usual care)
Interventions
BIOLOGICALPlatelet Poor Plasma (PPP)
BIOLOGICALPlatelet Rich Plasma (PRP)
Sponsors
Aspetar
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Acute onset posterior thigh pain * MRI confirmed Grade I, II hamstring lesions * \< 5 days from injury * Able to perform Physiotherapy at ASPETAR (5 sessions/week) * Available for follow-up * Male * Age \> 18 years
Exclusion criteria
* Diabetes, immuno-compromised state * Overlying skin infection * Re-injury or Chronic ongoing hamstring injury * Unwilling to comply with follow up * Contraindication to MRI * Needle Phobia * Bleeding disorder or other medical contraindication to injection * Medication increasing bleeding risk (e.g. Plavix) * Concurrent other injury inhibiting rehabilitation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to Return to Play | Patients will be followed for the duration of time to return to play with an expected average of 27 days and up to 1 year. | Time to return to full sports activity; either training or match play. |
Secondary
| Measure | Time frame |
|---|---|
| Recurrent hamstring lesions. | 2 months after return to play, 1 year after return to play. |
Other
| Measure | Time frame |
|---|---|
| Length and width of pain area during palpation and location of pain on palpation. | Once every 7 days from the inclusion date until the time to return to play. (The expected average return to play time is 27 days) |
| Passive straight leg raising test. | Once every 7 days from the inclusion date until the time to return to play. (The expected average return to play time is 27 days) |
| Full knee extension test at rest. | Once every 7 days from the inclusion date until the time to return to play. (The expected average return to play time is 27 days) |
| 90 degrees hip flexion test. | Once every 7 days from the inclusion date until the time to return to play. (The expected average return to play time is 27 days) |
| (Painful) resisted knee flexion test at 90 degrees. | Once every 7 days from the inclusion date until the time to return to play. (The expected average return to play time is 27 days) |
| Pain during walking, jogging, running, sprinting, acceleration and during training. | Once every 7 days from the inclusion date until the time to return to play. (The expected average return to play time is 27 days) |
| Slump test. | Once every 7 days from the inclusion date until the time to return to play. (The expected average return to play time is 27 days) |
| MRI scoring. | 3 weeks after date of injury. |
| Hamstring strength | At time of return to play (The expected average return to play time is 27 days) |
| Adverse effects. | Once every 7 days from the inclusion date until the time to return to play (the expected average return to play time is 27 days), 2 months after return to play, at the end of the sport season, and at 1 year after return to play. |
| Pain with resisted hip extension test at 30 degrees. | Once every 7 days from the inclusion date until the time to return to play. (The expected average return to play time is 27 days) |
| Pain with isometric contraction against resistance assessed with the visual analogue scale(VAS). | Once every 7 days from the inclusion date until the time to return to play. (The expected average return to play time is 27 days) |
Countries
Qatar
Outcome results
None listed